Meat Lover’s Pizza Casserole – Cheesy, Hearty, and Loaded with Flavor

If you love meat-loaded pizza, you’re going to fall in love with this Meat Lover’s Pizza Casserole. It has all your favorite pizza flavors—savory beef, pepperoni, sausage, gooey cheese, and rich tomato sauce—baked into one easy, comforting dish.

Perfect for busy weeknights, game day, or feeding a hungry crowd, this casserole is a guaranteed hit with kids and adults alike!

⭐ Why You’ll Love This Recipe

• ✔ All the flavors of meat lover’s pizza

• ✔ Easy, one-pan dinner

• ✔ Cheesy, hearty, and filling

• ✔ Great for family meals & potlucks

• ✔ Make-ahead and freezer-friendly

🛒 Ingredients

• 12 oz rotini or penne pasta

• 1 lb ground beef

• ½ lb Italian sausage (mild or hot)

• 1 cup pepperoni slices

• 1 (24 oz) jar pizza sauce or marinara

• 2 cups shredded mozzarella cheese

• ½ cup shredded cheddar or Colby-Jack cheese

• 1 small onion, diced

• 2 cloves garlic, minced

• 1 tsp Italian seasoning

• ½ tsp salt

• ½ tsp black pepper

• 1 tbsp olive oil

• Optional toppings: black olives, bell peppers, mushrooms

👨‍🍳 How to Make Meat Lover’s Pizza Casserole

Step 1: Cook the Pasta

Bring a large pot of salted water to a boil. Cook pasta until al dente. Drain and set aside.

Step 2: Brown the Meat

Heat olive oil in a large skillet over medium heat. Add onion and cook until soft. Add garlic, ground beef, and sausage. Cook until browned. Drain excess grease.

Step 3: Add Sauce & Seasoning

Stir in pizza sauce, Italian seasoning, salt, and pepper. Let simmer for 3–5 minutes.

Step 4: Combine Everything

In a large bowl, mix cooked pasta with the meat sauce and pepperoni slices.

Step 5: Assemble the Casserole

Preheat oven to 375°F (190°C).
Transfer mixture to a greased 9×13-inch baking dish. Top with mozzarella and cheddar cheese.

Step 6: Bake

Bake uncovered for 20–25 minutes, until bubbly and golden.

Step 7: Serve

Let rest 5 minutes. Slice and enjoy your pizza-style comfort food!

🍕 Tips for the Best Pizza Casserole

• Use full-fat mozzarella for the best melt

• Don’t overcook pasta—it will finish cooking in the oven

• Add veggies if you want a little balance

• Swap meats with bacon, ham, or turkey sausage

🥗 What to Serve With It

• Caesar salad

• Garlic bread

• Roasted green beans